ABSTRACT
OBJECTIVE: To construct and verify the incidence prediction model of occupational coal workers′ pneumoconiosis(CWP) in coal mine workers exposed to dust(hereinafter referred to as ″dust exposure″) based on a multi-layer perceptron(MLP) neural network, and explore its application value in predicting CWP incidence. METHODS: A total of 17 023 dust exposed workers in a coal mining group in Hebei Province from 1970 to 2017 were selected as the research subjects by a typical sampling method. Among them, 839 patients were confirmed as CWP and 16 185 workers did not suffered from CWP. The MLP neural network model was established with the incidence of CWP as the target output variable, and the type of work, age, beginning year of dust exposure, observation year(i.e. incubation period) and cumulative dust exposure as the input variable. The receiver operating characteristic(ROC) curve was used to evaluate the predictive ability of the built model. The established model was used to predict the high-risk group and key monitoring group population of CWP in dust-exposed workers in the following 10 years. RESULTS: There were 44 synapses in the hidden layer of the established MLP neural network model. The area under ROC curve was 0.91. The accuracy, sensitivity and specificity of the model were 92.7%, 74.8% and 93.6%, respectively. In the validation samples, the accuracy, sensitivity and specificity were 92.1%, 70.5% and 93.2%, respectively. The MLP neural network model was used to predict 1 534 workers with high risk of CWP in the following 10 years, and the individuals were located. The number of workers in need of actively monitored was 7 599. Among them, it is predicted that the incidence of CWP in different types of dust exposed workers in the following 10 years from high to low is tunneling worker, coal miner, mixing worker and auxiliary worker(P<0.01). The earlier the dust exposure began, the higher the risk of CWP(P<0.01). CONCLUSION: The MLP neural network model based on the type of work, age, beginning year of dust exposure, incubation period and cumulative dust exposure has a good performance in predicting the incidence of CWP in coal mine dust exposure workers, and can provide a reference for early preventive management measures to prevent and cure CWP.
ABSTRACT
Tic disorder （TD） is a neurodevelopmental disorder， with one or more motor and/or vocal disorders as the main symptoms. It brings many inconveniences to children's learning and life， and has a profound impact on children's character building. The pathogenesis of TD is mainly correlated with neurotransmitter release disorder， neuroimmune， genetic， trace element imbalance， diet and other factors， but has not been completely clear up to now. Western Medicine has obvious effects on TD， but with serious side effects. Compared with western medicine， traditional Chinese medicine （TCM） has the advantages of low adverse reactions and definite and lasting effect， and thus has been widely recognized by children and their families. In order to explore the pathogenesis of TD and the specific mechanism of TCM in the treatment of TD， many scholars have carried out a large number of in-depth animal experiments and made some achievements， but also exposed some defects， such as the single modeling method， failed to take into account other pathogenesis of TD， failure to combine the specific syndromes of TCM for targeted modeling， and failure to reflect the dialectic of TCM on the characteristics of governance. This paper reviews the modeling methods of common animal models， the comparison of advantages and disadvantages， and the changes of behavioral and biochemical indicators before and after the intervention with TCM compounds on TD animal models， so as to provide reference for the selection of animal models in future animal experimental research.